We hypothesize and test an inverse relationship between liquidity and price volatility derived from microstructure theory. Two important facets of liquidity trading are examined: thickness and noisiness. As represented by expected volume (thickness) and realized average commission cost per share (noisiness) of NYSE equity trading, both facets are found negatively associated with ex post and ex ante price volatilities of the NYSE stock portfolios and the NYSE composite index futures. Furthermore, the inverse association between volatility and noisiness is amplified in times of market crisis. The overall results demonstrate that volatility increases as noise trading declines. All findings retain statistical significance and materiality after controlling for a number of specifications. This inverse liquidity-volatility relationship reflects a microstructure interpretation of the liquidity risk premium documented in the asset pricing literature.