This paper examines how potential disruptions from generative artificial intelligence (AI) to firms' core businesses affect their cross-industry acquisition decisions. Using data on Chinese A-share listed firms, we employ a large language model to assess the potential positive and negative effects of generative AI on core businesses and construct a measure of net AI risk exposure. We measure cross-industry M&A using the semantic distance between acquirers' and targets' business descriptions. A difference-in-differences analysis exploiting the commercial diffusion of generative AI shows that more exposed firms acquire more distant targets, with an effect equivalent to 8.2% of the sample mean and robust to alternative specifications. The effect is stronger among firms with narrower innovation boundaries and more concentrated business portfolios, consistent with innovation capability reconfiguration and strategic risk diversification. It is also stronger among firms with smaller market shares, in more competitive industries, and in more marketized regions. Further analyses show that high-exposure firms acquire targets with higher AI patent shares and receive more favorable announcement-day market reactions to distant acquisitions. Our findings suggest that potential AI-related disruptions shape acquisition target selection and firms' business boundaries.