The northwest region of China faces many practical challenges, and its digital economy lags behind other areas of China. Digital transformation is a new source of competitive advantage in the digital economy era, which can help northwest enterprises rebuild their competitive advantage in the digital age, accelerate the development of the digital economy in the northwest region, bridge the digital gap between the East and the West, and promote the high-quality development of the national digital economy. In this study, the PLS-SEM method is used to collect data from 172 enterprises across five provinces in northwest China, to deeply analyze the mechanism and path through which digital transformation reshapes enterprise competitive advantage, identify the key sticking point hindering digital transformation in northwest China, and then propose more targeted strategic suggestions. It is found that the resource base of enterprises in northwest China is generally weak, making it difficult to deliver direct competitive advantage; existing enterprise resources can provide basic conditions for digital transformation and resource-orchestration capability; although digital transformation cannot directly create competitive performance, it can indirectly deliver competitive advantage by positively affecting resource-orchestration capability; resource-orchestration capability directly and significantly affects enterprise competitive performance and is the core competency for enterprises to build digital resilience.