The implementation of prefabricated housing (PH) has become prevalent in China recently because of its advantages in improving production efficiency and saving energy. However, the benefits of adopting PH cannot always be accrued by the stakeholders because of the arising transaction costs (TCs) in the projects’ development process. This study investigates the strategies for developers to make rational choices for minimizing the TCs of the PH project considering their own attributes and external constraints. A Bayesian Belief Network model was applied as the analytical method, based on the surveys in China. The single sensitive analysis indicated that developers influence the TCs of PH through the three most impactful factors: Prefabrication rate, PH experience, and Contract payment method. Furthermore, combined strategies were recommended for developers in various situations based on the multiple sensitivity analysis. Developers facing high prefabrication rate challenges are suggested to reduce the risks by procuring high-qualified general contractors and adopting unit-price contracts type. For developers with limited PH experience, adopting the Engineering-Procurement-Construction procurement method is the most efficient in reducing their TCs in the context of China’s PH market. This study contributes to the current body of knowledge concerning the effect of traders’ attributes and choices on TCs, expanding the application of TCs theory and fulfilling the study on the determinants of TCs in construction management.