Utilizing a national online survey we conducted in China, we examine the impact of COVID-19 on individuals’ willingness to take risks, willingness to trust other people, and mental health measured by the Center for Epidemiological Studies-Depression (CES-D) scale. Our findings suggest that people who live in the neighborhood with a higher number of confirmed cases became more risk-averse, less likely to trust others, and more depressed. Interestingly, the effects on risk preferences and trust attitudes are statistically significant only for men, and the effects on depression are statistically significant only for women. Furthermore, the impact of COVID-19 on financial decisions, such as buying new commercial insurance and making a risky investment, is also statistically significant only for men, which is consistent with our findings on risk preferences. Attitudes towards cadres and doctors mainly drive the results on trust attitudes. The change in employment status does not drive these effects.